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Cryo-SEM image of a mesenchymal cell encapsulated in a PEG-fibrinogen hydrogel after several days in 3-D culture
Cryo-SEM image of a mesenchymal cell encapsulated in a PEG-fibrinogen hydrogel after several days in 3-D culture
Read more about Cell-Compatible Hydrogels
PEG-fibrinogen hydrogels used in the regeneration of osteochondral defects in sheep; new bone and cartilage visible
PEG-fibrinogen hydrogels used in the regeneration of osteochondral defects in sheep; new bone and cartilage visible
Read more about Tissue Repair (Cartilage, Bone, Nerve)
Parallel plate rheometry measurements performed on PEG-fibrinogen hydrogels with UV-curing attachment
Parallel plate rheometry measurements performed on PEG-fibrinogen hydrogels with UV-curing attachment
Read more about Cell-Compatible Hydrogels
Dorsal root ganglion outgrowth into PEG-fibrinogen hydrogels after 1 week in culture; shown are neuronal cells (red) and glial cells (green)
Dorsal root ganglion outgrowth into PEG-fibrinogen hydrogels after 1 week in culture; shown are neuronal cells (red) and glial cells (green)
Read more about Tissue Repair (Cartilage, Bone, Nerve)
Cardiac myocytes cultured within PEG-fibrinogen hydrogels after several days; staining for α-Sarcomeric acti and DAPI
Cardiac myocytes cultured within PEG-fibrinogen hydrogels after several days; staining for α-Sarcomeric acti and DAPI
Read more about Cell Therapy (Skeletal, Muscle, Cardiac)
Mesenchymal cell spreading within PEG-fibrinogen hydrogels after 1 and 7 days in culture.
Mesenchymal cell spreading within PEG-fibrinogen hydrogels after 1 and 7 days in culture.
Read more about Three-dimensional (3D) Cellular Morphogenesis

Research Overview

The focus of our applied research is on the design of semi-synthetic protein-polymer hydrogels that can influence specific interactions with cellular systems. These hydrogels have undergone extensive validation and testing in pre-clinical and clinical settings. In parallel, some of the more basic scientific aspects of our research focus on using these hydrogels to understand the impact of matrix properties on the fate of stem cells and metastasizing cancer cells in 3D culture (i.e. mechanobiology).

Highlighted Publications

“Designing Cell-Compatible Hydrogels for Biomedical Applications”
Seliktar, D.,
Science, 336 (6085):1124-28, 2012 Read article >>

“The Biocompatability of PluronicF127 Fibrinogen-based Hydrogels”
Shachaf, Y., Gonen-Wadmany, M., Seliktar, D.,
Biomaterials, 31(10):2836-47, 2010

“Laser Engraving of Guidance Microchannels into Hydrogels Directs Cell Growth in 3-D”
Sarig-Nadir, O., Livnat, N., Zajdman, R., Shoham, S., Seliktar, D.,
Biophysical Journal, 3;96(11):4743-52, 2009